Laodikeia is located within the borders of the villages of Eskihisar, Goncalı, Korucuk and Bozburun, six km north of the modern city of Denizli. The site is on the road to Pamukkale (Hierapolis), which is approximately ten km to the north.
Laodikeia is also situated at the crossroads of main routes that connect western, central and southern Anatolia with each other. Set amid the fertile plains of the Lycos River, Laodikeia lies on a high plateau surrounded on three sides by rivers: the Lycos (modern Çürüksu) to the northeast, the Kapros (modern Başlıçay) to the southeast and the Asopos (modern Gümüşçay - Goncalı Deresi) to the northwest.
Laodikeia is one of the important archaeological remains for the region along with Hierapolis (Pamukkale) and Tripolis. Excavations at Laodikeia show that the city was settled continuously from the Chalcolithic Period (Copper Age, 5500 BCE) to 7th century CE. The name of the settlement was, in turn, Rhoas (Asopos Hill), Diopolis (City of Zeus) and finally Laodikeia.